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Experimental studies in Wistar rats treated with PZA or PA showed hepatotoxicity, as demonstrated by elevated serum alanine aminotransferase, aspartate transaminase, and galactose single-point levels (Tostmann et al., 2008
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Lastly, mitochondrial inhibition was shown to activate HIF-1 and its target genes shifting cellular metabolism away from catabolism and towards viral synthesis
Together with Bottazo et al
