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For example, the IRF4 gene affects how old a person is when their hair turns grey, and one variant is a marker for greying hair that starts too early

doi: 10.1016/0968-0004(88)90148-x

Their FAO suppression leads to reduced fatty acid breakdown and lipid accumulation, forming lipid-laden macrophages. These macrophages have severely impaired phagocytic function and cannot effectively clear apoptotic cells, foreign bodies, and cigarette smoke particles, further exacerbating the stability of the inflammatory microenvironment

NF-kappaB-dependent MnSOD expression protects adenocarcinoma cells from TNF-alpha-induced apoptosis

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First, how do DNA, RNA and protein methylation mutually regulate and synergistically influence ferroptosis under certain conditions, and what is the spatiotemporal regulatory relationship among them