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Oxidative stress has a negative impact on both bone tissue quality and bone catabolism [55]

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The effect can be related with a decrease of the NP stability in aqueous-suspension with the washing steps number, as it is revealed by the strong divergences between T2 and T2* and a major effect of the echo time used

A nasal spray is also available but is not considered the best treatment for severe deficiency because B12 is not absorbed as well as it is via injection

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