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For small molecules, refer to ICH guidance S2(R1) for recommendations on genotoxicity testing, which does not apply to biologics.9 Initially, a gene mutation assay (e.g., in vitro Ames test) will support a singledose trial

J.ZhaoY

At the juxtaparanodes, contactin-2 interacts with Caspr2, and this association is necessary for clustering of voltage-gated potassium channels

Zaman G

Delta Sleep-Inducing Peptide (DSIP): A review
