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Kurokawa et al., 2014a) and the action of the proteases (Saito et al., 2004

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In contrast, chronic excessive inflammation or tissue injury represents another potential consequence of trained immunity, contributing to the pathogenesis of diseases such as atherosclerosis, rheumatoid arthritis, psoriasis, and inflammatory bowel disease

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Those with known nutrient deficiencies (which COVID can worsen), people experiencing dehydration from fever or gastrointestinal symptoms, and individuals who have trouble with oral supplements due to digestive issues also tend to see significant benefits