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Pre-clinical research has reported an increase in VEGF and its receptor VEGFR2, and enhanced migration of endothelial cells

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Hence, both the ability to mount a proliferative response and the capacity to acquire a hair cell fate in response to Wnt overactivation decreases and becomes spatially more restricted in the neonatal cochlea compared to its embryonic counterpart

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(Gao et al., 2018) used cell culture models to study the effects of bleomycin and rapamycin on AFSCs senescence and differentiation

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