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J Periodontal Implant Sci

Rowland AS, Baird DD, Weinberg CR, Shore DL, Shy CM, Wilcox AJ

The therapeutic era of peptides began in 1921 with the discovery of insulin, a breakthrough that revolutionized diabetes and helped establish biologic therapies in medicine 1 Since then, peptide hormones like oxytocin and human growth hormone (GH) have entered clinical use, and glucagon-like peptide-1 (GLP-1) receptor agonists such as semaglutide are now widely prescribed for obesity and metabolic diseaseconditions increasingly recognized for their effect on orthopaedic outcomes

The reviewer YZ declared a shared affiliation with the authors to the handling editor at the time of the review

Fe2+ binding on amyloid -peptide promotes aggregation