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USA 118 , e2100784118 (2021)
Am J Psychiatry 2006
542 PF-06821497, a lactam-derived EZH2 inhibitor, was optimized from a series of similar compounds using ligand-based and physicochemical-property-based strategies, showing optimal inhibitory and therapeutic effects in mouse models
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In the subsequent activation of NF-B, pro-inflammatory cytokines are released
The endogenous production of creatine contributes an essential role in replenishing protein requirements and provides the smooth function of several vital organs
