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The term allergy was first coined in the early 1900s by Clemens von Pirquet (18741929), who was the first to recognize that antibodies not only mediate protective immune responses but can also be the cause of hypersensitivity reactions [9]

...A placebo is an inactive substance (often a sugar pill) given to a patient in place of medication

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A large study of the genetic factors contributing to serum UA has identified 183 loci, but still only explains about 7.7% of the variance 5

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