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Different delivery systems require different dose scales to achieve similar effects at target tissues

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Pao PC, Seo J, Lee A et al (2023) A Cdk5-derived peptide inhibits Cdk5/p25 activity and improves neurodegenerative phenotypes

Sometimes local treatments like ice, heat, deep friction techniques, acupuncture, ultrasound or electrotherapy can be beneficial

At some point, additional compounds provide no benefit while increasing cost, complexity, and potential side effects