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Conversely, the inflammation and immune responses triggered by pyroptosis release various inflammatory mediators and cytokines, such as interleukin-1 and interleukin-8, which might promote tumor growth, modify the tumor microenvironment, and contribute to drug resistance (133)

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1 Peak concentrations of 100mg SUBLOCADE may be lower than the range observed with TM BUP, while average and trough concentrations may be higher