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Kometani T, Yoshino I, Miura N, Okazaki H, Ohba T, Takenaka T, Shoji F, Yano T, Maehara Y (2009) Benzo[a]pyrene promotes proliferation of human lung cancer cells by accelerating the epidermal growth factor receptor signaling pathway

Multidrug Resistance-associated Protein 1 (MRP1) and MRP2, of the ABC (ATP-Binding Cassette)-type subfamily C transporters, transport oxidized glutathione and glutathione S-conjugates when expressed in yeast 58,59 and might be involved in their transport from the cytosol into the vacuole in plants

3.4 Immune-function activity Various species of mushrooms, particularly Pleurotus ostreatus and their lectin extracts, can enhance the activity of the defensive system in humans, as demonstrated in in vitro and in vivo studies (19)

To confirm the unbiased groups for the histology-based approach, we also performed a clustering analysis of the integrated object using the eight samples at 0.1, 0.3, and 0.5 resolution (Supplementary Fig

Future work should focus on validating its effects on key signaling pathways (e.g., NF-B, MAPK) and confirming these observations in vitro using human skin cell models

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