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Hypoxic Sertoli cells may produce fewer nutrients or regulatory factors, and hypoxic peritubular cells may release stress signals that negatively affect nearby germ cells

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or Have had optimal treatment with allopurinol, however, renal impairment means that probenecid cannot be added or is likely to be ineffective Patients who have had previous Special Authority approval for benzbromarone are also eligible for Special Authority approval for febuxostat (see: Benzbromarone to be discontinued)

These can include abdominal pain