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High-touch plastic and metal surfaces such as grab bars and railings should be cleaned routinely

This complexity underscores the need for stage-specific interventions: acute mitochondrial injury may respond to antioxidants or metabolic substrates, while advanced disease may require reprogramming of cellular bioenergetics

To overcome this, various techniques such as peptide cyclization, amino acid substitution with D-isomers, PEGylation, and encapsulation in carriers (e.g., nanoparticles, hydrogels) are being explored, though these approaches can increase complexity and production costs