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This mutation leads to detrimental phenotypes such as premature aging, senescence, immune deficiency, and neurodegeneration 111,288

A deficiency in B12 can lead to a significant decrease in energy and exercise tolerance, along with fatigue

Table 3: Vitamin B 12 Medication Table The table below is not an exhaustive list of all vitamin B 12 products and therapeutic considerations

While the implications for SARM1 in regulating axonal fate are well-established, the sensing mechanisms of this protein complex toward NAD + , NMN, or even possibly toward other NAD + metabolites are not fully understood, and may suggest that also the other NAD + metabolites could regulate more biological processes than initially thought 54

I run a Facebook support group for people living with B12 deficiency and Pernicious Anaemia