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Int J Parasitol (2013) 43:22531.10.1016/j.ijpara.2012.11.005 5 BrookerSBethonyJHotezPJ
Many mechanisms have been implicated in the development of IVDD, including inflammatory factors, oxidative stress, apoptosis, cellular autophagy, and mitochondrial dysfunction
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As above, the most used treatment in high-grade dysplasia is radiofrequency ablation

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The TGA has confirmed it is actively monitoring this issue from both a safety and law enforcement perspective