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Its main clinical manifestations are refractory hypoxia and respiratory insufficiency

4446,4952 In the early stages of atherosclerotic renal artery stenosis progressive decreases in blood flow are accompanied by compensatory changes in arteriovenous shunting, and decreases in glomerular filtration rate and tubular reabsorption of sodium, that either increase oxygen availability or reduce its consumption

Moreover, you are more likely to be deficient in this vitamin if you take certain medications, like: Metformin PPIs Histamine H2 blockers Oral contraceptives Chronic alcoholism can also damage your digestive system to the point that it can no longer sufficiently absorb vitamin B12

Vitamin C (ascorbic acid): High-dose vitamin C is acidic and can directly irritate the esophagus and stomach

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doi:10.1007/s12264-018-0269-8 22