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For the TMT-based relative quantification, the TMT reporter ion intensities in the MS/MS spectrum were considered for the calculation of the ratios, with the normalization method being set to auto normalization (on total protein), the mass error tolerance to 40 ppm and the FDR threshold to 1.0%

While proteasomal dysfunction is correlated with age progression and protein aggregation, proteasome activation slows the aging progress down and increases longevity (Saez and Vilchez, 2014)

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So far, however, only very few enzymes have been found to show cystine reductase activity in vitro, and their physiological roles remain to be determined [117]

High-Dose Supplement Led to Excess Vitamin B12: Q

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