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The classical theory believes that the mtDNA release is mediated by the opening of the mitochondrial permeability transition pore (MPTP) (Patrushev et al., 2004)

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ATP (adenosine tri-phosphate) is literally the currency of all cellular activity, facilitating DNA and RNA synthesis and triggering muscular contraction during explosive, high-intensity physical activity

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In contrast, evidence of cardioprotection of acetyl-L-carnitine was investigated in 2002 by Heger et al., who demonstrated that oral administration of acetyl-L-carnitine promotes the process of -oxidation and prevents aging-related oxidative stress in older murine hearts (Hagen et al., 2002)

Integrated metagenomics identifies a crucial role for trimethylamine-producing Lachnoclostridium in promoting atherosclerosis