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Yes, moderate physical activity is even recommended as it improves circulation and peptide delivery to tissues
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doi: 10.1146/annurev-cellbio-120420-015303 114 LuYLiZZhangSZhangTLiuYZhangL

doi: 10.2119/molmed.2013.00102

However, that will only happen if fatigue is caused by being B12 deficient before the shots are started

Its important to monitor levels and consult with a healthcare provider before starting treatment
