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Alteration in gut microbiota is associated with immune imbalance in graves disease

Trimigno et al

Based on the metabolomics analysis we identified a total of 32 differential metabolites that were significantly reversed by TGP, and discovered 8 key metabolic pathways, including phenylalanine, tyrosine and tryptophan biosynthesis, phenylalanine metabolism, histidine metabolism, starch and sucrose metabolism, arginine and proline metabolism, arginine biosynthesis, glutathione metabolism, and purine metabolism

Activation of autophagy can cause changes in ferritin

Cirrhosis alone had an even greater effect (HR 24.1)

Pro-apoptotic elements, BCL2 associated X, apoptosis regulator (BAX) and BCL2 antagonist/killer 1 (BAK1), drive processes such as mitochondrial outer membrane permeabilization and the creation of the mitochondrial permeability transition pore (MPTP), thus regulating the formation of pores in the outer mitochondrial membrane [112]