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By crossing a mouse model of DS (the Tc1 mouse) that does not have an additional copy of APP to a transgenic mouse overexpressing APP with AD-causing mutations (J20 mouse), the additional copy of Hsa21, independent of an extra copy of APP , exacerbated A aggregation and deposition, enhanced APP transgene-associated mortality, altered behavior, and reduced cognitive performance in double-mutant progeny that model DSAD (477)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 91.Kitano Y., Hashimoto S., Matsumoto H

January 12, 2016

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Another report found a case of scurvy following KD use in a 5-year-old girl on the autism spectrum (64)