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Description
VISTA is an inhibitory immune checkpoint that is increased after ipilimumab therapy in patients with prostate cancer
No effects on IGF-1, glucose, or insulin Phase IIa: 300 obese subjects, 12 weeks, multiple dose groups (1mg, 5mg, 10mg, 20mg, 30mg SC daily)
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Ongoing research is needed to clarify the complex and interacting pathophysiological mechanisms at play, as well as to identify upstream triggers for disease (such as environmental exposures)
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doi: 10.3390/antiox10101541 6 AungT.EunJ
