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By contrast, knocking out NF-B regulatory protein A20 in microglia was associated with massive microglia activation, neuroinflammation, and increased EAE pathology (44)

J Neurosci Res 68:6575 Chen Y, Vartiainen NE, Ying W, Chan PH, Koistinaho J, Swanson RA (2001) Astrocytes protect neurons from nitric oxide toxicity by a glutathione-dependent mechanism

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Many solid tumors show little to no response to ICIs or develop acquired resistance, largely due to the immunosuppressive state of the tumor microenvironment, often referred to as cold tumors [356]