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It has also been demonstrated that suppression of energy generation significantly increases sensitivity to excitotoxicity.[104] Excitotoxicity, as well as inflammation, stimulates the generation of NO by microglia and astrocytes, which directly suppresses mitochondrial function

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Unlike GLP-1 agonists, the changes are compositional rather than scale-weight driven: patients may not lose significant total body weight but will show meaningful reduction in waist circumference and visceral fat volume

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