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TGF--dependent signaling, activated by soluble endoglin and growth differentiation factor 15, promotes inflammatory chemokines in the ovary and pelvic adhesions, contributing to reduced fertility (44)

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Moreover, the ability of polyphenols to penetrate the BBB is compound specific and often suboptimal, necessitating advanced delivery strategies such as nanoformulations or prodrugs to enhance CNS targeting (Ramakrishna et al

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The first pharmacometabolomics studies on acetaminophen aimed to identify the biomarkers of drug-induced liver injury (DILI) [86,87]

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doi: 10.2460/ajvr.2004.65.1100

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Its return to normal in liver disease is an excellent indicator

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HFrEF, heart failure with reduced ejection fraction

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