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Given the predominance of Cu(I) and the involvement of multiple copper-trafficking molecules, intracellular copper distribution is governed by affinity gradients among cuproproteins and copper-binding compounds
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Long-term studies show no adverse effects on kidney function in healthy individuals 8

Disturbances in lipid metabolism represent the primary cause of fatty liver, which in MASLD manifests as the accumulation of triglycerides (TG) in hepatocytes

Refrigeration and proper sealing are non-negotiable for maintaining research-grade stability

This metabolic perturbation induces sustained ER stress through unfolded protein overload, culminating in mitochondrial decompensation, exacerbating ROS production and establishing a vicious cycle of mitochondrial decline (153,154)

The MDS-UPDRS scores were recorded before and after the intervention
