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Our previous studies have reported similar evidence in hepatocytes with low B12 demonstrating upregulation of FA and TG synthesis [14], and increased adiposity via hypomethylation and upregulation of the master regulators of lipogenesis (SREBF1) and cholesterologenesis (LDLR) in adipocytes [13]
Personalized Genome-Scale Modeling Reveals Metabolic Perturbations in Fibroblasts of Methylmalonic Aciduria Patients

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