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[DOI] [PMC free article] [PubMed] [Google Scholar] 164.Reyes CD, Garcia AJ

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The depletion of tryptophan in the TME impairs effector T cell function, while kynurenine degradation products can suppress tumor immunity by inducing the generation of Foxp3+ regulatory T cells (Tregs) (134)

However, this dosing is from animal studies and has not been validated for human use