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Beyond cancer, PRODH dysfunction is also linked to neuropsychiatric and metabolic diseases, including schizophrenia 65,66 , and hyperprolinemia type I 67 , reflecting its broader role in regulating mitochondrial redox balance and prolineglutamate neurotransmitter metabolism

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Additional research areas Published studies have examined dopaminergic and serotonergic system modulation, oxidative stress markers in neuronal models, and the pharmacokinetic properties of the Pro-Gly-Pro stability extension a design shared with the related peptide Selank (tuftsin + PGP)

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Mohammed S, Alsafadi K, Enaruvbe GO, Harsnyi E