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Nervous system and stress tolerance B12 deficiency doesn't just affect mood directly it degrades your capacity to handle stress
Zhang Y, Chen S, Wei J, Jiang J, Lin X, Wang Y, Hao C, Wu W, Yuan Z, Sun J, et al

To sum up, some patients report the worsening of symptoms within the first few days or weeks when they begin B12 shots

They lose the ability to absorb B12 as they can for other nutrients
Given that B12 is a water-soluble vitamin, the majority of an injected dose is excreted through urine, leaving only a small fraction for absorption