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The peptide has been studied extensively across various organ systems, demonstrating cytoprotective effects in the gastrointestinal tract, liver, pancreas, heart, blood vessels, muscle, tendon, ligament, bone, and nervous system

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Chung CK, Fransen MF, van der Maaden K et al (2020) Thermosensitive hydrogels as sustained drug delivery system for CTLA-4 checkpoint blocking antibodies

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While collagen is a component of cartilage extracellular matrix, GHK-Cus effects appear more pronounced in skin and connective tissue rather than cartilage specifically