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Description
It has to distinguished that the replacement therapy should be only undertaken to restore the physiological levels, never to exceed physiological ranges

Adding 2 mL of water creates a 25 mg/mL concentration

Vitamin B12 Deficiency Anemia

Over-dosing or skipping titration steps can cause severe nausea, dehydration, gastroparesis (delayed stomach emptying), and in rare cases pancreatitis or hypoglycemic events

The prepared solid dispersions have shown higher solubility in the phosphate buffer pH 7.4 than pH 6.8 and 1.2 [29]

Glim JE, Beelen RH, Niessen FB, Everts V, Ulrich MM