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Gene expression analysis revealed Clock expression in leukocytes decreased 1.8-fold, Cry2 expression doubled, and Csnk1e expression in lymphocytes decreased 2.1-foldall statistically significant changes indicating re-entrainment of disrupted circadian oscillations

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and markers of thrombosis and endothelial cell activation including plasminogen activator inhibitor-1 (PAI-1), protein C, protein S, Von Willebrand factor (vWF), factor IX, intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion protein 1 (VCAM-1) (Fig
