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If the elevation is unexplained, reducing B12 isnt the goal

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doi:10.1056/NEJMoa060900 Martinelli M, Scapoli L, Palmieri A, Pezzetti F, Baciliero U, Padula E, Carinci P, Morselli PG, Carinci F (2006) Study of four genes belonging to the folate pathway: transcobalamin 2 is involved in the onset of non-syndromic cleft lip with or without cleft palate

This suggests that there's still a need for extra human research trials to provide definitive outcomes [12]

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