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For example, multiple studies found lower abundance of Firmicutes 46 , 64 and Ruminococcus 43 , 48 , 68 (genus or species), and higher abundance of Butyricimonas , 45 , 46 Dorea , 46 , 48 Prevotella , 48 , 50 Sutterella , 46 , 50 and Bacteroides 48 , 50 genera or species, in post- vs pre-menopausal women or in women with lower estrogen

The focus was on: the number of sperm cells being produced, the overall quality of the sperm cells, as well as improving the all-important DNA package within the sperm cells, improving both natural conception and assisted reproduction

2019;252(Pt B):151931

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This is particularly significant given that sex differences are observed in response to some drugs, including the prevalence of adverse events (Anderson, 2005