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GHK-Cu is predominantly found in saliva, blood, and urine, and has multiple biological actions when administered to test subjects, including [1]: Antioxidant gene activity [2] Suppression of inflammatory cytokine interleukin-6 [2] Increased protein accumulation [3] Increased collagen synthesis [3] In animal models, GHK-Cu has been shown to increase an anti-inflammatory proteogly called decorin that can protect diabetic rats from kidney-damaging fibrosis [2, 4]

Biotechnol Lett 25:887890

Transcriptional regulation of the antioxidant response element

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[DOI] [PubMed] [Google Scholar] 136.Demirkol O., Adams C., Ercal N