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ChaC1 is downstream of the protein kinase R-like ER kinase (PERK)/eukaryotic initiation factor-2 (eIF2)/activating transcription factor (ATF) 4/ATF3/CCAAT/enhancer binding protein (C/EBP) homologous protein (CHOP) pathway, serving as a pro-apoptotic and pro-ferroptosis component downstream of UPR

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Juul A, Scheike T, Davidsen M et al (2002b) Low serum insulin-like growth factor I is associated with increased risk of ischemic heart disease: a population-based case-control study

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In glucose + FA perfused hearts, NR reduced IR injury, increased glycolytic intermediate phosphoenolpyruvate (PEP), TCA intermediate succinate and PPP intermediates ribose-5P (R5P) / sedoheptulose-7P (S7P), and was associated with activated glycolysis, without changes in TCA cycle or PPP activities

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His extensive experience with concussion patients throughout the Atlanta area has established Cook Vision Therapy Center as a leading destination for post-concussion vision rehabilitation

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NADPH oxidase-4 mediates protection against chronic load-induced stress in mouse hearts by enhancing angiogenesis

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