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Pharmacodynamics of dimethyl fumarate are tissue specific and involve NRF2-dependent and -independent mechanisms

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To identify the cell death type induced by PQS, we used several cell death inhibitors, including ferrostatin-1 (Fer-1, a ferroptosis inhibitor), Necrostatin-1 (NEC, a necroptosis inhibitor), Z-VAD (VAD, a pan-caspases inhibitor to block apoptosis), Disulfiram (DIS, a pyroptosis inhibitor), and 3-methyladenine (3-ME, an autophagy inhibitor), before PQS treatment followed by a CCK-8 assay

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