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GSH depletion triggered by the Nrf2/ATF3/4/ChaC1 pathway appears to be the primary factor inducing death in drug-resistant tumor cells (138), positioning ChaC1 as a key target for certain potential anti-tumor drugs such as busatol (139) and glaucocalyxin A (140)

E.Lund LaursenT.Teicher KirkF.VilstrupH.AlaA.GormsenL

Authier F, Ondruskova N, Ferenbach AT, McNeilly A, van Aalten DMF

Multiple targeted self-emulsifying compound RGO reveals obvious anti-tumor potential in hepatocellular carcinoma

Professional supervision ensures safe administration and optimal results

Mitochondrial dysfunction in sepsis: mechanisms and therapeutic perspectives