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Description
Discovery of 7-Methyl-5-(1-[3-(Trifluoromethyl)Phenyl]Acetyl-2,3-Dihydro-1h-Indol-5-Yl)-7h-Pyrrolo[2,3-D]Pyrimidin-4-Amine (Gsk2606414), a potent and selective first-in-Class inhibitor of protein kinase r (Pkr)-like endoplasmic reticulum kinase (Perk)
Two caveats deserve emphasis
Dose reduction remains the most reliable solution if water retention becomes genuinely bothersome

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1,13 Spironolactone might also be helpful in treating hair loss and acne related to androgen excess
