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Annu Rev Physiol 75:127154
A ligand that is received by a receptor on the plasma membrane will usually not enter the cell
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It is characterized by perioral and mucocutaneous pigmentations, gastrointestinal polyposis, and an increased risk of cancer in adulthood.61 Pigmentations are seen in approximately 95% of the patients and constitute an early clinical sign, before any gastrointestinal symptoms
