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Therapeutic doses of vitamin C may act against cancer development and progression through several other mechanisms, such as stimulating immune system activation or enhancing the chemosensitivity of cancer cells, but evidence beyond preclinical models is still lacking (124, 125)

Battisti, M

It also modulates systemic mineral balance by suppressing parathyroid hormone (PTH) and fine-tuning the FGF23Klotho signaling axis (41, 42), thus preserving calciumphosphate homeostasis and bonekidney axis integrity

At least 300 pathogenic mutations in POLG have been defined to date

Only peer-reviewed English articles were included in this study

C.MadiganM