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A., Cannell, J

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Cancer-associated adipocytes exhibit phenotypic changes including secretion of the lipids, inflammatory cytokines, and an imbalance in adipokine signaling pathways, such as the upregulation of leptin and downregulation of adiponectin, which promote tumor proliferation and invasion (123)
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The tight junction is organized by four types of transmembrane proteins, occludin, claudins, tricellulin and junctional adhesion molecules, which interact with the scaffold proteins such as ZO-1, ZO-2 and ZO-3 (62, 63)

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