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The levels of these peptides were upregulated in the epidermis, offering novel insights into the immunoregulatory mechanisms associated with skin aging ( 5.2 Quantitative proteomics Quantitative proteomics specifically identifies protein species and quantities while quantifying differences between healthy and diseased groups, thus generating taxonomic models that yield critical insights into molecular interactions, key signaling pathways, and biomarker screening (Zhang et al., 2023)

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doi: 10.1016/j.isci.2022.103827 183 SivandzadeFPrasadSBhaleraoACuculloL

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3, 4, 5 However, it is the paracellular pathway, regulated by the tight junction (TJ), that is responsible for the greatest degree of apical cellcell adhesion, 6, 7 and which has received the most attention for its role in regulating mucosal permeability under normal and pathological conditions