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Description
The peptide's mechanism involves disrupting the FOXO4-p53 interaction specifically in replication-stressed senescent chondrocytes, triggering selective apoptosis while preserving healthy proliferative cells needed for cartilage formation
Polymeropoulos, M
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This document was developed with the primary intent of protecting clinical trial participants from potential adverse effects of new compounds
2021;896 doi: 10.1016/j.ejphar.2021.173913
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