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doi: 10.1016/j.bbrc.2016.11.017 135 GengJYangCWangBZhangXHuTGuYet al

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In some models, vitamin B supplementation was even associated with a small increase in fasting insulin, raising concerns about possible unfavorable metabolic effects

354 Furthermore, the PKM2-HIF-1 axis stimulates the release of inflammatory mediators, such as IL-1, further exacerbating the inflammatory response

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