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Siegl and Rudel, 2015[206]

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Furthermore, reduced expression of mitochondrial biogenesis genes, such as PGC-1 and NRF1, in GCs of atretic follicles suppresses the mitogen-activated pathway kinase (MAPK)/extracellular signal-regulated kinases (ERK) signaling pathway, which is necessary for initiating mitochondrial biogenesis

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Additionally, high ROS concentrations within particular organelles can oxidize cellular constituents, such as membrane lipids, indicated by an increase in the lipid peroxidation by-product malondialdehyde (MDA), as well as carbohydrates, proteins, and DNA 7