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Description
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In a rodent model of amphetamine-induced neurotoxicity, NAC reversed striatal dopamine depletion and significantly reduced oxidative damage markers, such as lipid peroxidation and hydroxyl radical production [99]

Biochemical assays Lipid peroxidation (LPO) was assessed as thiobarbituric acid reactive substances (TBARS) in terms of formed malondialdehyde (MDA) according to a method described by Ohkawa et al

The results of the study demonstrated that miR-124-3p sEVs safeguard DA neurons from 6-OHDA-induced damage in both in vitro and in vivo models, ultimately leading to complete motor function recovery in vivo

The above findings strongly indicate that oxidative stress, particularly at the level of the mitochondria, plays a central role in the neuronal death that underlies a diverse group of neurodegenerative diseases
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