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In addition, compared with other single treatments, the cell death rate and active caspase-3 in the combined treatment were increased significantly, and the CD133 + stem cell-like cell pool in osteosarcoma was eliminated to a greater extent 26 (Figure 3 and Table 1)

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CD44 is expressed on leukocytes and has a role in mediating the innate immune response

Beyond this threshold, nasal absorption becomes increasingly unreliable due to physical limitations in transmucosal permeation